REDOX HOMEOSTASIS AND CELL CYCLE ACTIVATION MEDIATE BETA-CELL MASS EXPANSION IN AGED, DIABETES-PRONE MICE UNDER METABOLIC STRESS CONDITIONS: ROLE OF THIOREDOXIN-INTERACTING PROTEIN (TXNIP)

Overnutrition contributes to insulin resistance, obesity and metabolic stress, initiating a loss of functional beta-cells and diabetes development.Whether these read more damaging effects are amplified in advanced age is barely investigated.Therefore, New Zealand Obese (NZO) mice, a well-established model for the investigation of human obesity-asso

Multi-turn charge-exchange beam injection is the key technique to achieve high-intensity proton beam accelerators.In J-PARC RCS, 400-MeV H- beams from LINAC are injected into stripper foils such that most of the beams are converted into protons.The stripper foils are irradiated not only with the injected ngetikin H- beams but also with the protons

Cells adhere to ngetikin substrates through mechanosensitive focal adhesion complexes.Measurements that probe how cells detach from substrates when they experience an applied force connect molecular-scale aspects of cell adhesion with the biophysical properties of adherent cells.Such forces can be applied through shear devices that flow fluid in a

OBJECTIVES/SPECIFIC AIMS: Opioid use disorder (OUD) is a national epidemic and identified as a top priority by the practices and communities in rural Colorado.Until recently, few resources existed to address OUD in rural communities.In addition to training primary care and behavioral health practice teams in medication assisted treatment (MAT), Imp